منابع مشابه
Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions.
The different populations of dopaminergic neurons located in the ventral mesencephalon have long been associated with distinct functional roles. The nigrostriatal projection is considered necessary for efficient motor performance, while the mesolimbocortical projection is usually associated with reward signalling. However, a number of recent studies in our laboratory suggest that the divergence...
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Methamphetamine's widepread abuse and concerns that it might increase Parkinson's disease led us to assess if the reported loss of dopamine transporters (DAT) in methamphetamine abusers (MA) reflected damage to dopamine neurons. Using PET with [(11)C]cocaine to measure DAT, and with [(11)C]raclopride to measure dopamine release (assessed as changes in specific binding of [(11)C]raclopride betwe...
متن کاملAlterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice.
Dopamine (DA) autoreceptors expressed along the somatodendritic extent of midbrain DA neurons modulate impulse activity, whereas those expressed at DA nerve terminals regulate both DA synthesis and release. Considerable evidence has indicated that these DA autoreceptors are of the D2 subtype of DA receptors. However, many pharmacological studies have suggested an autoreceptor role for the DA D3...
متن کاملAtrial natriuretic hormone is not elevated during dopamine induced natriuresis.
To evaluate the possibility that atrial natriuretic hormone (ANH) is involved in dopamine induced natriuresis and diuresis, we studied five normal male volunteers. Each was studied on two occasions. During the first two hours of each study, normal saline, 25 ml/hr, was infused. During the second two hours either normal saline, 25 ml/hr, or dopamine, 4 micrograms/kg/min, in normal saline, was in...
متن کاملPhysiological and Pharmacopathological Role of Dopamine Receptors and Brain Dopamine Systems
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ژورنال
عنوان ژورنال: Addiction
سال: 2012
ISSN: 0965-2140
DOI: 10.1111/j.1360-0443.2011.03591.x